Bachelor in Mechanical Engineering / Master in Biomedical Engineering
Francisco Serrano Alcalde.
Mechanical engineer specialized in computational simulation of cells and cells cultures using the Finite Element Method (FEM). The main models developed are focused on studying and understanding the mechanosensing mechanisms of cells that trigger cell differentiation or migration processes under different conditions. Furthermore, Fluid-Structure Interaction (FSI) models have been developed studying the effect of creeping flows on cells and scaffold deformations using Coupled Eulerian-Lagrangian (CEL) meshes and co-interaction techniques.
Cellular migration, cellular modelling, cell mechanosensing
The role of nuclear mechanics in cell deformation under creeping flows.
Francisco Serrano-Alcalde, José Manuel García-Aznar and María José Gómez-Benito.
Journal of Theoretical Biology. DOI: 10.1016/j.jtbi.2017.07.028.
Cell biophysical stimuli in lobopodium formation: a computational based approach.
Francisco Serrano-Alcalde, osé Manuel García-Aznar and María José Gómez-Benito.
Computer Methods in Biomechanics and Biomedical Engineering.
Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially-infected epithelial cells.
Effie E. Bastounis, Francisco Serrano-Alcalde, Prathima Radhakrishnan, Patrik Engström, María José Gómez-Benito, Mackenzi S. Oswald, Yi-Ting Yeh, Jason G. Smith, Matthew D. Welch, José Manuel García-Aznar, Julie A. Theriot.
Developmental cell. Accepted
Professional activities and achievements.
R&D engineer at Multiphysics and Multiscale Simulation division of the Technological Institute of Aragon (ITAINNOVA). Main tasks: development of FEM models of polymers, from the production stage to the component and life prediction.