Dr. in Applied Medicine and Biomedicine

Javier Martínez García .

Position: Senior Researcher. Margarita Salas postdoctoral fellow.
Phone:

(+34) 976 71 58 95

Email:

jmartinez@iisaragon.es

Graduate in Biochemistry, University of Murcia (2016). PhD in Applied Medicine and Biomedicine from the University of Navarra. Thesis work on bile acid-regulated expression systems for gene therapy of cholestasis at CIMA University of Navarra (2021).

Currently, Margarita Salas postdoctoral fellow at the Department of Mechanical Engineering in the University of Zaragoza in collaboration with the Digestive Pathology group of the Aragón Health Research Institute. The main line is the determination of the therapeutic and regenerative potential of translational tools in germ-free mouse models and models of acute and chronic liver disease.

Profile

My research areas include:

– Gene therapy of genetic cholestasis.

– Intracellular signaling in MDR phenotype and antineoplastic drug resistance.

– Therapeutic tools for the treatment of acute and chronic liver diseases.

– Generation of bioengineered livers and the use of liver organoid technology.

Full list of publications available here

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Nuclear magnetic resonance spectroscopy measure of protein glycosilation and lipoprotein profile are biomarkers of metabolic associated fatty liver disease in inflammatory bowel disease.

García-Mateo S. #; SJ. Martínez-Domínguez SJ. #; Gargallo-Puyuelo CJ.; Gallego B.; Alfambra E., Aso MC.; Martinez-Micaelo N.; Amigó N; Ribalta J.; Guardiola M.; Martínez-García J.; Baptista PM.; Gomollón F.

Journal of Crohn’s and Colitis.

2023 (under review)

Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma.

Guillermo Herrador-Cañete; Marta Zalacain; Sara Labiano; Virginia Laspidea; Montserrat Puigdelloses; Lucía Marrodan; Marc Garcia-Moure; Marisol Gonzalez-Huarriz; Javier Marco-Sanz; Iker Ausejo-Mauleon; Daniel de la Nava; Reyes Hernández-Osuna; Javier Martínez-García; Noelia Silva-Pilipich; Elisabet Guruceaga; Ana Patiño-García; Rubén Hernández-Alcoceba; Cristian Smerdou; Marta M. Alonso.

Molecular Therapy Oncolytics.

2022

A minimal bile salt excretory pump promoter allows bile acid‐driven physiological regulation of transgene expression from a gene therapy vector.

Martínez-García J.; Molina M.; Odriozola L.; Molina A.; González-Aseguinolaza G.; Weber ND.; Smerdou C.

Cell & Bioscience.

2022