José Manuel García Aznar .

ICoMICS
2022-2026

Individual and Collective Migration of the Immune Cellular System.

European Research Agency
ERC-2020-Advanced Grant (GA Nr 101018587).

VASTO
2023-2025

VAScularised Tumour Organoids on a chip with human placenta vessels as a preclinical model for anticancer therapies.

European Research Agency
ERC-2023-POC (GA Nr 101138214).

METASTRA
2023-2028

Computer-Aided Effective Fracture Risk Stratification of Patients with Vertebral Metastases for Personalised Treatment through Robust Computational Models Validated in Clinical Settings

European Union
HORIZON-HLTH-2022-TOOL-12-01-two-stage (GA Nr 101080135).

Tumatrix-Modeling
2022-2025

Predictive modeling and simulation of patient-derived tumor organoids: unraveling the role of matrix stiffness and glucose metabolism on tumor growth.

National Research Agency
Spain (PID2021-122409OB-C21).

Tumor-on-chip
2019-2021

Microfluidics, mechanobiology and image analysis for 3D tumor growth simulation.

National Research Agency
Spain (RTI2018-094494-B-C21).

Primage
2018-2022

Predictive insilico multiscale analytics to support cancer personalized diagnosis and prognosis, empowered by imaging biomarkers.

European Union
H2020-SC1(Health),(GA 826494).

Curabone
2011-2021

Predictive models and simulations in bone regeneration: a multiscale patient-specific approach.

European Union
H2020-REA MSCA ITN,  (GA 722535).

Insilico-cell
2012-2016

Predictive modelling and simulation in mechano-chemo-biology: a computer multi-approach.

European Research Council Starting Grant
Project Number: 306571

Cad-bone
2012-2016

Patient-specific predictions for bone treatments. Marie Curie Actions—Industry-Academia Partnerships and Pathways (IAPP)

In collaboration with Materialise and KU Leuven

A hybrid physics-based and data-driven framework for cellular biological systems: Application to the morphogenesis of organoids.

Camacho-Gomez, D., Sorzabal-Bellido, I.,  Ortiz-de-Solorzano, C., Garcia-Aznar, J.M., Gomez-Benito, M.J.

Iscience, 26(7).

2023

3D collagen migration patterns reveal a SMAD3-dependent and TGF-β1-independent mechanism of recruitment for tumour-associated fibroblasts in lung adenocarcinoma.

Juste-Lanas, Y., Díaz-Valdivia, N., Llorente, A. , ….,  Garcia Aznar JM, et al.

British Journal of Cancer, 128(6), 967-981.

2023

Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity.

Pérez-Rodríguez S, Huang SA, Borau C, García-Aznar JM, Polacheck WJ.

Biomicrofluidics, 15(5), 054102.

2021

Extracellular matrix density regulates the formation of tumour spheroids through cell migration.

Gonçalves IG, Garcia-Aznar JM. 

PLoS computational biology, 17(2), e1008764.

2021

Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells. 

Bastounis EE, Serrano-Alcalde F, Radhakrishnan P, Engström P, Gómez-Benito MJ, Oswald MS, Yeh YT, Smith JG, Welch MD, García-Aznar JM, Theriot JA.

Dev Cell. 56(4):443-460.e11.

2021

Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation.

Escribano J, Chen MB, Moeendarbary E, Cao X, Shenoy V, Garcia-Aznar JM, Kamm RD, Spill F.

PLoS Comput Biol. 15(5):e1006395.

2019

From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β

Merino-Casallo F, Gomez-Benito MJ, Juste-Lanas Y, Martinez-Cantin R, Garcia-Aznar JM

Sci Rep. 8(1) : 12723.

2018

Degradation of extracellular matrix regulates osteoblast migration: A microfluidic-based study.

Movilla N., Borau C., Valero C., García-Aznar J.M.

Bone, 107, 10-17.

2018

Force loading explains spatial sensing of ligands by cells.

Oria, R, Wiegand, T, …, García-Aznar JM, et al.

Nature, 552(7684) , 219-224.

2017

Collective cell durotaxis emerges from long-range intercellular force transmission

Sunyer R, …, García-Aznar J.M., et al.

Science, 353(6304), 1157-1161.

2016