Dr. Industrial Engineer.

José Manuel García Aznar .

Position: Full Professor of Structural Mechanics
Phone:

(+34) 976 762 796

Email:

jmgaraz@unizar.es

Fax:

(+34) 976 762 670

Skype:

jmgaraz_manu

BSc in Mechanical Engineering, University of Zaragoza, Spain (1995). PhD in Computational Mechanics from the University of Zaragoza; Thesis work on computational simulation of bone remodeling (1999). Post-doctorate fellow at the Center for Science and Technology in Medicine, University of Keele, United Kingdom (2001), working on computational simulation of tissue differentiation in bone fracture healing. Currently, Full Professor of the Department of Mechanical Engineering in the University of Zaragoza.

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ICoMICS
2022-2026

Individual and Collective Migration of the Immune Cellular System.

European Research Agency
ERC-2020-Advanced Grant (GA Nr 101018587).

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tumor-on-chip

Tumor-on-chip
2019-2021

Microfluidics, mechanobiology and image analysis for 3D tumor growth simulation.

National Research Agency
Spain (RTI2018-094494-B-C21).

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Primage
2018-2022

Predictive insilico multiscale analytics to support cancer personalized diagnosis and prognosis, empowered by imaging biomarkers.

European Union
H2020-SC1(Health),(GA 826494).

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Curabone
2011-2021

Predictive models and simulations in bone regeneration: a multiscale patient-specific approach.

European Union
H2020-REA MSCA ITN,  (GA 722535).

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Insilico-cell
2012-2016

Predictive modelling and simulation in mechano-chemo-biology: a computer multi-approach.

European Research Council Starting Grant
Project Number: 306571

Cad-bone
2012-2016

Patient-specific predictions for bone treatments. Marie Curie Actions—Industry-Academia Partnerships and Pathways (IAPP)

In collaboration with Materialise and KU Leuven

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Computational mechanics:

  • Non-linear FEA
  • Multiscale and Multiphysics Analysis
  • Discrete models

Computational mechanobiology:

  • Mechanics of hard tissues
  • Implant design and testing
  • Mechanobiology of skeletal tissue regeneration
  • Computer tissue engineering
  • Tissue growth and development
  • Cell mechanics and mechanotransduction
  • Cell migration: microfluidics

Self-healing materials:

  • Expansive clays

Full list of publications available here

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Primary human osteoblasts cultured in a 3D microenvironment create a unique representative model of their differentiation into osteocytes.

Nasello, G., Alamán-Díez, P., Schiavi, J., Pérez, M. Á., McNamara, L., & García-Aznar J.M. 

Frontiers in Bioengineering and Biotechnology, 8, 336.

2020

A multi-scale modelling framework combining musculoskeletal rigid-body simulations with adaptive finite element analyses, to evaluate the impact of femoral geometry on hip joint contact forces and femoral bone growth..

Kainz H, Killen BA, Wesseling M, Perez-Boerema F, Pitto L, Garcia Aznar JM, Shefelbine S, Jonkers

PLoS One, 15(7): e0235966.

2020

Nonlinear elasticity of the lung extracellular microenvironment is regulated by macroscale tissue strain.

Jorba I, Beltrán G, Falcones B, Suki B, Farré R, García-Aznar JM, Navajas D

Acta Biomater. 92:265-276.

2019

Breast Cancer Cells Adapt Contractile Forces to Overcome Steric Hindrance

Cóndor M, Mark C, Gerum RC, Grummel NC, Bauer A, García-Aznar JM, Fabry B.

Biophys J. 116(7):1305-1312.

2019

Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation.

Escribano J, Chen MB, Moeendarbary E, Cao X, Shenoy V, Garcia-Aznar JM, Kamm RD, Spill F.

PLoS Comput Biol. 15(5):e1006395.

2019

Image-based Characterization of 3D Collagen Networks and the Effect of Embedded Cells.

Olivares V, Cóndor M, Del Amo C, Asín J, Borau C, García-Aznar JM

Microsc Microanal. 25(4): 971-981.

2019

Matrix degradation regulates osteoblast protrusion dynamics and individual migration

Movilla N, Valero C, Borau C, García-Aznar JM

Integr Biol (Camb). 11(11) : 404-413.

2019

Modelling actin polymerization: the effect on confined cell migration

Hervas-Raluy S, Garcia-Aznar JM, Gomez-Benito MJ

Biomech Model Mechanobiol. 18(4) : 1177-1187.

2019

Combined experimental and computational characterization of crosslinked collagen-based hydrogels

Valero C, Amaveda H, Mora M, García-Aznar JM

PLoS One. 13(4) : e0195820.

2018

From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β

Merino-Casallo F, Gomez-Benito MJ, Juste-Lanas Y, Martinez-Cantin R, Garcia-Aznar JM

Sci Rep. 8(1) : 12723.

2018

Integration of in vitro and in silico Models Using Bayesian Optimization With an Application to Stochastic Modeling of Mesenchymal 3D Cell Migration.

Plou J, Juste-Lanas Y, Olivares V, Del Amo C, Borau C, García-Aznar JM

Front Physiol.9: 1246.

2018

Force loading explains spatial sensing of ligands by cells.

Oria, R., Wiegand, T., Escribano, J., Elosegui-Artola, A., Uriarte, J. J., Moreno-Pulido, C., Platzman I, Delcanale P, Albertazzi L, Navajas D, Trepat J, García-Aznar JM, Ada Cavalcanti-Adam E, Roca-Cusachs P

Nature, 552(7684) , 219-224.

2017

Collective cell durotaxis emerges from long-range intercellular force transmission

Sunyer R, Conte V, Escribano J, Elosegui-Artola A, Labernadie A, Valon L, Navajas D, García-Aznar J.M., Muñoz JJ, Roca-Cusachs P, Trepat X.

Science, 353(6304), 1157-1161.

2016

Numerical simulation of solid deformation driven by creeping flow using an immersed finite element method.

Rüberg, T., & García-Aznar, J. M.

Engineering Sciences, 3(1), 1

2016

Computational model of mesenchymal migration in 3D under chemotaxis

Ribeiro, F. O., Gómez-Benito, M. J., Folgado, J., Fernandes, P. R., & García-Aznar, J. M

Computer Methods in Biomechanics and Biomedical Engineering, 1-16.

2016

Professional activities and achievements.

  • Vice-President of the European Society of Biomechanics (2008-2012).
  • Associate Director of the Biomedical Engineering Division of I3A (Aragón Institute of Engineering Research).
  • Director Board Member of the Virtual Physiological Human Institute.
  • Editorial Board membership of Computer Modeling in Engineering and Sciences (2019-), Computer Methods in Biomechanics and Biomedical Engineering (2019-), Computational Particle Mechanics (2014-), PlosOne (2014-) and Bone (2011-).
  • Juan C. Simo Young Investigator Award by SEMNI (2004).